Aufau International Award 2016 | Young Scientist Award | Chemical Sciences

Dr. Sugasini Dhavamani,

Postdoctoral Researcher,

Division of Endocrinology and Diabetes,

Department of Medicine,

University of Illinois, USA.

Sugasini

The Post doctoral research experience in USA on Molecular forms of docosahexaenoic acid (DHA) and their uptake by the brain. Preferential uptake of the lysophosphatidylcholine (LPC) form in an in vitro model of blood brain barrier (BBB)- endothelial cells and Astrocytes and inflammatory mediators of cytokines, flow cytometry and ROS. In vivo effect of omega-3 PUFA uptake on Alzheimers disease mice models and lipidomics part (triglycerides, Phospholipidomics, sphingolipidomics, ceramides and plasmologens) by LCMS/MS, GCMS, HPLC. I did my Ph.D (Biochemistry) in CSIR–CFTRI under the supervision of Dr.B.R.Lokesh. The doctoral research in CSIR-CFTRI was to study the effect of nanoencapsulated linseed oil to enrich omega-3 fatty acids in hepatic, cardiac and brain lipids in rats and it has to be helpful for vegetarian sections of Indian Population. Recent developments in the field of nanotechnology are exploited by many investigators for the delivery of biologically important molecules.Our aim is to increase the bioavailability of alpha linolenic acid (ALA) and possibly enhance its conversion to long chain omega-3 PUFA in rats give nanoparticles of linseed oil using liposomes. Earlier I had worked on some collaborative projects in the calorific value and of diacylglycerol oil (DAG oil) in rats and rabbit models. Later I had worked on hypocholesterolemic effect of rats and rabbits fed structured lipids of enzymatic interesterification and chemical interesterification. Here we evaluated total cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL), very low density lipoprotein (VLDL), apolipoprotein, Triglyceride and Phospholipids in serum, liver, white adipose tissue of rats and rabbits. We also had seen the histopathology of aorta of rabbits (atherosclerosis). I also worked on Minor constituents removed rice bran oil and sesame oil has reduced ability to modify lipid homeostasis and inflammatory mediators in rats as compared to native oils. Evaluation of antiradical, anti-inflammatory and antioxidant properties of extracts from Indian red chilli and black pepper, other nutraceutical compounds in vitro and in vivo models (Indo Bulgarian Project-DST Grant project). With these experience on Biochemistry, lipidomics, nutrition, cell biology and molecular biology. We are able to publish in peer reviewed International journals such as Lipids, Molecular and cellular biochemistry, Food Chemistry, Nutritional Neuroscience, Journal of Functional foods and few more research papers are communicated and under preparation. I had presented our research in International and National conferrences.

I had received many awards and fellowships from CSIR Diamond Jubilee award, ICMR, ICAR, UGC and TNAU. I had worked with DBT, DST,CSIR and ICMR funded projects and some of the collaborated projects with IICT and Indo Bulgarian project. I had received many gold medals in under graduate and postgraduate programmes. Recently I received prestigious award of NIH funded postdoctoral award, Young Gandhian Technological innovation award in Indian president house Rasthrapathi Bhavan for the innovation of our research work and Best research scholar award, highest cumulative impact paper award from CSIR. UGC postdoctoral Fellowship award, Best student award for best researcher and highest cumulative point in CSIR-CFTRI, ICMR research fellowship award, CSIR diamond jubilee Research Fellowship award, ICAR Merit fellowship award, National Eligibility Assistant professorship award by UGC/CSIR/ASRB, India. Thiru. R, Chidambaram and Dr. Punjab singh Award for University first rank holder in MS, Shri. P.A.C. Ramaswamy Raja Prize, Thiru Krishnakant Award, Baarreddy and Kamiredy award for University first rank holder in BS,

I am the member of some scientific Societies like American oil chemists society (AOCS), American Federation of Medical Research (AFMR), American Society of pharmacology and experimental Therapeutics (ASPET), American society of Mass spectrometry (ASMS), Society of Biological Chemists(SBC), Indian Science Congress, American Institute of Biological Sciences(AIBS), International Food Technology (IFT).